Research Guide of Hungary

3. Medicine

3.1 Biomedical Sciences
3.2 Clinical Sciences
3.3 Pharmacology and Pharmaceutical Sciences
3.4 Multidisciplinary Medical Sciences
3.5 Interdisciplinary Medical Sciences

3.1 Institute for Experimental Medicine, the Hungarian Academy of Sciences
(Magyar Tudomanyos Akademia Kiserleti Orvostudomanyi Kutatointezete)

Contact:
Beata Sperlagh
Deputy Director
Institute of Experimental Medicine of the Hungarian Academy of Sciences
P. O. Box 67., H-1450 Budapest, HUNGARY
+36 1 210 9400
Sperlagh@koki.hu

Research, a Short Introduction:
The Institute, located in Budapest, is the only research institution in Hungary dedicated exclusively to medical research. Its activity focuses on basic biomedical research, primarily in the field of Neuroscience, including studies on neurotransmission, learning and memory, behaviour, ischaemic and epileptic brain damage, as well as the central and peripheral control of hormone secretion. The research teams of the Institute employ multidisciplinary approaches: traditional, well-established methodologies (e.g. in Anatomy, Electrophysiology, Neurochemistry and Pharmacology) are combined with novel cellular and molecular biology techniques as well as patch clamp and calcium imaging techniques.

The Institute welcomes Ph.D. students and young post-doctoral researchers subject to individual negotiation for 6 months. Knowledge of English is essential.

The Institute would also like to participate in international Research and Development Projects.

3.1 Department of Physiology, Semmelweis University
(Elettani Intezet, Semmelweis Egyetem)

Contact:
Gabor Czirjak
Assistant Lecturer
Department of Physiology Semmelweis University
P. O. Box, 259., H-1444 Budapest, HUNGARY
+36 1 266 2755 ext. 4113
czirjak@puskin.sote.hu

Research, a Short Introduction:

• Regulation of Effector Functions of Phagocytic cells
• Regulation of Plasma Membrane Receptors
• Mitochondrial Function
• Physiology of Potassium Channels

The Institute welcomes young researchers in the fields of Regulation of Effector Functions of Phagocytic cells, Regulation of Plasma Membrane Receptors and Physiology of Potassium Channels for 1 year or more. Knowledge of English or Hungarian is essential.

The Department would also like to take part in international Research and Development Projects.

3.1 Ph.D. School for Biomedical Sciences, University of Pecs
(Elmeleti Orvostudomanyi Doktori Iskola, Pecsi Tudomanyegyetem)

Contact:
Professor Janos SZOLCSANYI
Head of The Ph.D. School
Ph.D. School for Biomedical Sciences Department of Pharmacology and Pharmacotherapy
University of Pecs
Szigeti u. 12., H-7602 Pecs, HUNGARY
+36 72 536 217
janos.szolcsanyi@aok.pte.hu

Research, a Short Introduction:
The Ph.D. School contains 4 major and 11 associated programmes for postdoctoral training both in basic and clinical sciences. The programmes are closely related to high quality research supported either by the Hungarian Academy of Sciences or a variety of Foundations and are carried out in over 10 Departments and Research Groups organised within the University. The programmes cover many important fields of Neuropharmacology, Neurosciences, Neuroendocrinology and Immunology, and have strong international relations including collaboration, joint research and publications as well as exchange of students and senior scientists.

The Institute welcomes Ph.D. students, post-doctoral and young and senior researchers in the fields of Neuropharmacology, Neurosciences, Neuroendocrinology, Molecular Biology, Microbiology and Immunology for 1 year. Knowledge of English is necessary.

The Ph.D. School would also like to take part in international Research and Development Projects.

3.1 Ph.D. School for Medical Sciences, Semmelweis University
(Elmeleti Orvostudomanyok Doktori Iskola, Semmelweis Egyetem)

Contact:
Professor Emil Monos
Head Ph.D. School for Medical Sciences
Department of Human Physiology Semmelweis University
Ulloi ut 78/a., H-1082 Budapest, Hungary
+36 1 210 6038
monos@elet2.sote.hu

Research, a Short Introduction:

• Ischaemic cardiovascular diseases — physiological and clinical aspects;
• Mechanisms of normal and pathological functions of the circulatory system;
• Biological effects of ionising and non-ionising radiation;
• Renal physiology and pathophysiology from molecules to bedside;
• Cardiovascular effects of endogenous cardio- and vasoactive substances as well as pharmacological preparations — physiological and pathophysiological aspects.

The Institute welcomes PhD students and young pre- or post-doctoral researchers for stays of 6 months and less or 1 year and more. Knowledge of English is necessary.

The Ph.D. School would also like to take part in international Research and Development Projects.

3.1 Neurophysiology Research Group, the Hungarian Academy of Sciences and the University of Pecs
(Idegelettani Kutatocsoport, Magyar Tudomanyos Akademia es Pecsi Tudomanyegyetem)

Contact:
Professor Laszlo Lenard
Director and Chairman
Research Group for Neurophysiology, the Hungarian Academy of Sciences
Faculity of Medicine
Institute of Physiology
University of Pecs
P. O. Box 99., H-7602 Pecs, Hungary
+36 72 536 243
Laszlo.Lenard@aok.pte.hu

Research, a Short Introduction:
Limbic mechanisms of endocrine regulation. Oestrogen receptors. Central regulation of hunger, satiety and body weight. Glucose receptor cells in the limbic system. Taste and odour related information processing. Motivation, learning and reinforcement. Neurochemical mechanism of perception and addictive behaviour.

The Institute welcomes Ph.D. students, post-doctoral and young and senior researchers in Neurophysiology, Neuroanatomy, Neurochemistry, Endocrinology, Behavioural Sciences research fields for less than 6 months and 1 year. Knowledge of English is necessary.

The Research Group would also like to take part in international Research and Development Projects.

3.1 Research Group for Neurobiology, the Hungarian Academy of Sciences and Semmelweis University
(Neurobiologiai Kutatocsoport, Magyar Tudomanyos Akademia es Semmelweis Egyetem)

Contact:
Jozsef Takacs
Senior Researcher
Research Group for Neurobiology, the Hungarian Academy of Sciences
Department of Anatomy
Semmelweis University
Tuzolto u. 58., H-1094 Budapest, HUNGARY
+36 1 215 6920, +36 1 217 6937

Research, a Short Introduction:

Neuroanatomy, neurobiology:
• Postnatal development, transmitter and receptor immunohystochemical architecture and plasticity of the cerebellum
• Morpho-functional changes following sensory deprivation; cross-modal plasticity.

Psychophysiology, psychophysics:
• Types and mechanisms of visual attention
• Perceptual learning and plasticity of visual attentional modulation.

Mathematical neurobiology (computer simulation):
• Role of spike-trains in the possible coding of neuronal information in simple neuronal networks

The Institute welcomes Ph.D. students in Neuroanatomy, Neurobiology, Psychophysiology, Psychophysics, Mathematical Neurobiology (computer simulations) for an academic year. Knowledge of English is necessary.

The Research Group would also like to take part in international Research and Development Projects.

3.1 Research Group for Molecular Genetics, the Hungarian Academy of Sciences and Eotvos Lorand University
(Molekularis Genetika Kutatocsoport, Magyar Tudomanyos Akademia es Eotvos Lorand Tudomanyegyetem)

Contact:
Professor Laszlo Orosz
Chairman
Research Group for Molecular Genetics, the Hungarian Academy of Sciences
Department of Genetics
Eotvos Lorand University
Pazmany Peter Setany, H-1117 Budapest, HUNGARY
+36 1 209 0555
orosz@falco.elte.hu

Research, a Short Introduction:

• Developmental Genetics: Signalling Pathways, Mesoderm Differentiation, and Bone Morphogenesis.
• Model Systems: Ccaenorhabditis Elegans, Development of Red Deer’s Antler
• Prokaryotic Genetics: DNA-protein Sequence Specific Bindings, Site-specific Recombination, Molecular genetics of industrial micro-organism

The Institute welcomes Ph.D. students and pre-doctoral researchers in the fields of Molecular Genetics (developmental genetics on lacnorhabditis elegans, bone morphogenesis on antler) and Microbial Genetics (bacteria of agricultural and industrial use) from 6 months to 1 year or more. Knowledge of English or Hungarian is necessary.

The Research Group would also like to take part in international Research and Development Projects.

3.1 Research Group for Molecular Genetic, the Hungarian Academy of Sciences and the Semmelweis University
(Molekularis Genetikai Kutatocsoport, Magyar Tudomanyos Akademia es Semmelweis Egyetem)

Contact:
Rudolf deChatel
Chairman
Molecular Genetic Research Group, the Hungarian Academy of Sciences
Semmelweis University
Koranyi Sandor u. 2/a, H-1083 Budapest, HUNGARY
+36 1 210 0279

Research, a Short Introduction:
Early genetic reprogramming in the course of experimental cardiac hypertrophy. Development of cardiac hypertrophy in diabetes mellitus. The influence of dietary fatty acid on cardiac hypertrophy. Natriuretic peptides as markers of tissue proliferation in the cardiovascular system.

The Institute welcomes Ph.D. students and pre-doctoral researchers in Cardiovascular physiology research fields for up to 6 months. Knowledge of English or Hungarian is necessary.

The Research Group would also like to take part in international Research and Development Projects.

3.1. Research Group for Membrane Biology and Immunopathology, the Hungarian Academy of Sciences and Semmelweis University
(Membranbiologiai es Immunkortani Kutatocsoport, Magyar Tudomanyos Akademia es Semmelweis Egyetem)

Contact:
Balazs Sarkadi
Head of Research Group
Research Group for Membrane Biology and Immunopathology, the Hungarian Academy of Sciences
Semmelweis University
Dioszegi u. 64, H-1113 Budapest, HUNGARY
+36 1 372 4353
sarkadi@biomembrane.hu

Research, a Short Introduction
The Membrane Biology and Immunology Research Group works in the area of membrane transport proteins, investigating their function and regulation. Primary research projects focus on the investigation of the physiological and pharmacological role of the family of ABC (ATP Binding Cassette) transporters, including various multidrug resistance (MDR) proteins.

The name of the MDR proteins refers to their potential role in clinical multidrug resistance, a phenomenon that hinders the effective chemotherapy of tumours. Numerous xenobiotics are eliminated from the cells by the sequence of oxidation, conjugation to an anionic group (glutathione, glucuronate or sulphate) and transport across the plasma membrane into the extracellular space. These transport processes are also mediated by the MDRs. The projects of the group include the investigation of several other ABC transporters, including those involved in cellular lipid metabolism (ABCA1 and ABCG1), and other diseases (CFTR, MRP6, etc.).

The Group performs the expression and characterisation of mutant human MDR protein variants, studies specific regions of these proteins. Members of the Group also develop new fluorescence-based transport assays for the transporters, and characterise clinically applicable new compounds for their interactions with these proteins.

The Institute welcomes Ph.D. students and post-doctoral young researchers in the fields of Membrane Biology, Biochemistry, Molecular Biology for one academic year or more. Knowledge of English is necessary.

The Research Group would also like to take part in international Research and Development Projects.

3.1 Research Group for Neuroendocrine, the Hungarian Academy of Sciences and Semmelweis University
(Neuroendokrin Kutatocsoport, Magyar Tudomanyos Akademia es Semmelweis Egyetem)

Contact:
Bela Halasz
Research Professor
Research Group for Neuroendocrine, the Hungarian Academy of Sciences
Department of Human Morphology and Developmental Biology
Semmelweis University
Tuzolto u. 58., H-1094 Budapest, HUNGARY
+36 1 218 6064
gerendai@ana2.sote.hu

Research, a Short Introduction:
The Research Group of the Hungarian Academy of Sciences has been dealing with neuroendocrinology for about three decades and the Hungarian Academy of Sciences made several contributions to the field, providing data on the afferents of the hypophysiotrophic neurones, the asymmetry of the Neuroendocrine system, autocrine and paracrine mechanisms, and on neuronal pathways involved in the control of pituitary adenohypophysial hormones. The Research Group is interested in the structural and functional organisation of the hypothalamo-adenohypophysial-target endocrine gland system.

Currently the Group is investigating: (1) the neuromorphology and functional significance of glutamatergic innervation of hypothalamic cell groups, (2) neuronal connections between the gonads and central nervous system structures and their role in the control of testosterone secretion and (3) the control of prolactin secretion

The Institute would welcome pre-doctoral researchers in Neuroendocrine fields, such as glutamatergic innervation of the hypothalamus, neural control of testosterone secretion and control of prolaction secretion research field for 6 months or 1 year. Knowledge of English is essential.

The Research Group would also like to participate in international Research and Development Projects.

3.1 Research Group for Antibiotics, the Hungarian Academy of Sciences and the University of Debrecen
(Antibiotikum-szerveskemiai Kutatocsoport, Magyar Tudomanyos Akademia es Debreceni Egyetem)

Contact:
Istvan Pelyvas
Senior Research Fellow
Research Group for Antibiotics, the Hungarian Academy of Sciences Department of Pharmaceutical Chemistry
University of Debrecen
Egyetem ter 1., H-4010 Debrecen, HUNGARY
+36 52 512 900 ext. 2472
pelyvas@tigris.klte.hu, antibiotics@tigris.klte.hu

Research, a Short Introduction:
The Research Group works in close co-operation with the Department of Pharmaceutical Chemistry at the University of Debrecen, and takes part in the basic teaching programs of students in Chemistry and Pharmacy. The Group is carrying out intensive scientific research on the structural elucidation, chemical synthesis, and structural modification of various antibiotics and related microbial products, including carbohydrate-containing representatives, beta-lactam antibiotics and beta-lactamase inhibitors, etc. Further major research topics are: utilisation of carbohydrates and another substances as chiral pools in natural products syntheses, molecular medicinal chemistry and drug design, computer-assisted molecular modelling of organic substances, and examination of the biomolecular recognition and structural features of organic substances by nuclear magnetic resonance (NMR) methods.

The Group, along with Hungarian Academy of Sciences has developed fruitful international scientific collaboration with institutes at the major European and overseas academies.

The Institute welcomes Ph.D. students and young post-doctoral or senior researchers for 6 months or 1 year or more. In our post-graduate (Ph.D.) program the following major research topics are involved: search for new methodologies and reagents in organic synthesis, synthesis of glycopeptide-, carbohydrate-containing- and beta-lactam antibiotics and their building blocks, de novo synthesis of carbohydrates, utilisation of carbohydrates and another substances as chiral pools in natural products syntheses, and examination of the biomolecular recognition and structural features of organic substances by nuclear magnetic resonance (NMR) method. Knowledge of English, Russian or German is essential.

The Research Group would also like to participate in international Research and Development Projects.

3.1 Research Group for Cell and Immunobiology, the Hungarian Academy of Sciences and Semmelweis University
(Molekularis Immunologiai Kutatocsoport, Magyar Tudomanyos Akademia es Semmelweis Egyetem)

Contact:
Professor Andras Falus
Chairman
Research Group for Cell and Immunobiology, the Hungarian Academy of Sciences
Department of Genetics
Semmelweis University
Nagyvarad ter 4, H-1089 Budapest, HUNGARY
+36 1 210 2929
faland@dgci.sote.hu

Research, a Short Introduction:
Research at the Group concentrates on Molecular Cell Biology and Immunology.
Major topics:

• Histamine Biology (immunology, molecular genetics on Transgenic animals) focusing on the role of histamine in tumours and the phenotype of histamine free mice
• Structural and Functional Genomics of Oncology (including chemokine variants in asthma as well as gene expression pattern of ALL children)
• T Cell repertoire and Epitope Hierarchy in Experimental Arthritis Induced by Proteoglycans
• Stem Cell Research, the Gene Expression Pattern of Human (umbilical) and Mouse (embryonic) Stem Cells

The Research Group welcomes Ph.D. students, pre- and post-doctoral and young researchers in the fields of Immunology, Clinical Genomics and Molecular Cell Biology for stays of 6 month to one academic year. Knowledge of English is necessary.

The Research Group would also like to take part in international Research and Development Projects.

3.2 Ph.D. School for Clinical Sciences, University of Debrecen
(Klinikai Orvostudomanyi Doktori Iskola, Debreceni Egyetem)

Contact:
Gyula Szegedi
Full Professor
Ph.D. School for Clinical Sciences
3rd Department of Internal Medicine
University of Debrecen
Moricz Zs. utca 22., H-4004 Debrecen, Hungary
+36 52 414 ext. 969, +36 52 311 ext. 087
szegedi@iiibel.dote.hu

Research, a Short Introduction

• Clinical Immunology
• Clinical Oncology
• Epidemology of Diseases

The Institute welcomes PhD students and young post-doctoral researchers in Clinical Immunology for less than 6 months. Condition: mutual exchange of PhD students with other Departments. Knowledge of English is necessary.

The Ph.D. School would also like to take part in international Research and Development Projects.

3.2 Department of Medical Genetics and Child Development, University of Pecs
(Orvosi Genetikai es Gyermekfejlodestani Intezet, Pecsi Tudomanyegyetem)

Contact:
Gyorgy Kosztolanyi
Head, Department
Department of Medical Genetics and Child Development
Medical Faculty
University of Pecs
Jozsef Attila u. 7., H- 7623 Pecs, HUNGARY
+36 72 535 977
gyorgy.kosztolanyi@aok.pte.hu

Research, a Short Introduction:

• Genetic Background of Mental Retardation
• Mitochondrial Diseases
• Genetic Instability

The Department welcomes Ph.D. students and young post-doctoral researchers in the Aetiology of Mental Retardation for less than 6 months. Knowledge of English and/or German is necessary.

The Department would also like to take part in international Research and Development Projects.

3.2 Research Group for PET, the Hungarian Academy of Sciences and University of Debrecen
(PET Kutatocsoport, Magyar Tudomanyos Akademia es Debreceni Egyetem)

Contact:
Lajos Tron
Head of Department
Research Group for PET, the Hungarian Academy of Sciences
PET Centre
Medical and Health Science Centre
University of Debrecen
Bem ter 18C, H-4026, Debrecen, HUNGARY
+36 52 431 958
tron@pet.dote.hu

Research, a Short Introduction:
Based on a relatively high number of diagnostic investigations using positron emission tomography special studies are conducted on the role and value of this technique in the oncology, neurology and cardiology. Aiming the localisation of different mental functions, brain activation studies are carried out using ¹⁵O-labelled butanos as brain perfusion tracer. Parallel to the above investigations radiochemical development programs are in progress to synthesise receptor specific ligands labelled with the positron emitting isotopes ¹⁸F (110 min half life) and ¹¹C (20 min half life).

The Institute welcomes Ph.D. students, pre- or post-doctoral and young and senior researchers in the fields Brain Activation (using the PET method), Development and Biological/Pharmacological Evaluation of Receptor Specific Radioligands for 6 months or 1 year and more. Knowledge of English is necessary.

The Research Group would also like to take part in international Research and Development Projects.

3.2 Research Group for Nephrology and Paediatrics, the Hungarian Academy of Sciences and of Semmelweis University
(Gyermekgyogyaszati es Nephrologiai Kutatocsoport, Magyar Tudomanyos Akademia es Semmelweis Egyetem)

Contact:
Barna VASARHELYI
Associate Professor
Research Group for Nephrology and Paediatrics, the Hungarian Academy of Sciences
First Department of Paediatrics
Semmelweis University
Bokay u. 53., H-1083, Budapest, HUNGARY
+36 1 266 2755 ext. 2725
vasbar@gyer1.sote.hu

Research, a Short Introduction:
Recent studies indicate that endothelial dysfunction plays a central role in the development of acute and chronic vascular complications of preterm neonates. At the Research Laboratory of the First Department of Paediatrics, Semmelweis University we focus on the inflammatory, hormonal and free-radical mediated pathogenic processes that might lead to the erosion of the inner layer of vasculature. For this purpose, several experimental and clinical studies are being under way.

In in vitro experiments, lymphocytes are isolated from septic neonates and their cytosine production is tested under various external stimuli. The responsiveness of lymphocytes was altered in septic neonates compared to healthy ones.

Animal experiments are used to shed light on the importance of cytosine and heat shock protein gene expression in the defence against ischemia-reperfusion injury. We found, that sexual steroid hormones through these agents might have profound effect on the progression and severity of renal lesions following ischemia-reperfusion.

In clinical settings, we have proven, that during the first postnatal days a quick decrease of blood iron levels might play a role in the antioxidant defence of the neonates against reactive oxygen species injury.

Genetic analyses of nearly 200 preterm neonates suggest, that the presence of some interleukine and renin-angiotensin gene polymorphisms leading to exaggerated inflammatory and vascular response might be associated with increased risk for patent ductus arteriosus, acute renal failure, narcotising enterocolitis and bronchopulmonary dysplasia in preterm babies.

Our epidemiological studies indicate that low birth weight is associated with higher blood pressure, more intense bone turnover and altered adrenal hormone levels in apparently healthy young adults.

The Research Laboratory would like to participate in international Research and Development Projects.

3.3 Institute of Pharmaceutical Chemistry, University of Szeged
(Gyogyszerkemiai Intezet, Szegedi Tudomanyegyetem)

Professor Ferenc Fulop
Head, Institute
Institute of Pharmaceutical Chemistry
University of Szeged
Eotvos u.6., H-6720 Szeged, HUNGARY
+36 62 54 55 64
fulop@pharma.szote.u-szeged.hu

Research, a Short Introduction:
Synthetic Organic Chemistry, Medicinal Chemistry, Drug Research, Heterocyclic chemistry.
Enantioselective Transformations, Synthesis of Small Natural Molecules, Enzyme-catalysed Selective Transformations, Combinatorial Chemistry, Peptide Foldamers: Design, Synthesis, Structure Investigations (see research activities on Institute’s web-site: http://www.szote.u-szeged.hu/gyki/indexe.htm

The Institute welcomes Ph.D. students and pre- or post-doctoral young researchers in the fields of Heterocyclic Chemistry, Enantioselective Transformations, Synthesis of Small Natural Molecules, Enzyme-catalysed Selective Transformations, Combinatorial Chemistry, Peptide Foldamers: Design, Synthesis, Structure Investigations for 6 months, 1 year and more. Knowledge of English is essential.
The Institute would like to have Ph.D. student with a masters degree in Chemistry or Pharmacy. The Institute would accept pre- and post-doctoral researchers, too.

The Institute would also like to participate in international Research and Development Projects.

3.3 Ph.D. School for Pharmacological Sciences, University of Debrecen
(Gyogyszertudomanyi Doktori Iskola, Debreceni Egyetem)

Contact:
Professor Lajos Gergely
Head, Ph.D. School
Ph.D. School for Pharmacological Sciences
Institute of Medical Microbiology
Institute of Pharmacology
University of Debrecen
P.O.Box 17., H-4012 Debrecen, HUNGARY
+36 52 417 565
mikro@jaguar.dote.hu

Research, a Short Introduction:
Pharmacology:

• Neuro-humoral regulations of insulin sensitivity
• Ischaemia induced alterations in diabetic heart muscle

Microbiology:

• Human papillomavirus infections of the lower genital tract
• Human immunodeficiency virus infections of natural killer cells

The Ph.D. School welcomes Ph.D. students and post-doctoral and young researchers in Pharmacology Medical virology: herpes-, papilloma- and retroviruses research fields for an 1 year. Knowledge of English is necessary.

The Ph.D. School would also like to take part in international Research and Development Projects.

3.3 Ph.D. School for Pharmaceutical and Pharmacological Sciences, Semmelweis University
(Gyogyszertudomanyi Doktori Iskola, Semmelweis Egyetem)

Contact:
Istvan Antal
Associate Professor
Ph.D. School for Pharmaceutical and Pharmacological Sciences
Department of Pharmaceutics Semmelweis University
Hogyes u. 7., H-1092 Budapest, HUNGARY
+36 1 217 0914
antist@hogyes.sote.hu

Research, a Short Introduction:
The Ph.D. School forPharmaceutical and Pharmacological sciences focuses on two scientific disciplines:

• Pharmacological research is needed to select new active substances, to develop and use medicinal products. In addition, new scientific results and discovered relationships may help to understand functions of human living organism.
• Pharmaceutical research is related to drug research, development of drug delivery systems as well as it is a prerequisite to produce and apply pharmaceutical preparations. Although pharmaceutical science involves the knowledge of other disciplines (e.g. chemistry and medical science), but the evaluation of medicinal products requires specialised knowledge from the viewpoint of this interdiciplinary science.

The Ph.D. School welcomes Ph.D. students, pre- and post-doctoral and young and senior researchers in the following fields:

Study of bioactive substances of plant origin in connection with photochemical and biological evaluation as well as biotechnological production; pharmaceutical chemistry and analysis; design, manufacturing and biopharmaceutical evaluation of novel dosage forms; clinical pharmacy and pharmacoeconomics; study of organic compounds with potential bioactivity; investigation of medical and pharmaceutical aspects of biology and environmental protection; pharmacodynamic investigations; pharmacokinetic and drug metabolism; influence on Neurochemical transmission; study of neurodegenerative and neuroprotective mechanisms; cardiovascular pharmacological investigations; separation methods and their applications; study of drugs affecting on calcium and bone metabolism; human study of cytostatic drugs; role of iontransport mechanisms controlling Neurochemical transmission for up to 1 year.

Knowledge of English or German is necessary.

The Ph.D. School would also like to take part in international Research and Development Projects.

3.4 1st Ph.D. Department of Pathology and Experimental Cancer Research, Semmelweis University
(1. Pathologiai es Kiserleti Rakkutato Intezet, Semmelweis Egyetem)

Contact:
Istvan Petak
Senior Scientist
1st Department of Pathology and Experimental Cancer Research
Semmelweis University
Ulloi ut 26, H-1085 109, Budapest, HUNGARY
+36 1 317 1074
ipetak@fulbrightweb.org

Research, a Short Introduction:
Special research interests: 1. Oncopharmacogenomics: Identification and functional analysis of genes involved in drug sensitivity especially those, which regulate apoptosis and cell survival. Identification of new molecular markers to better predict prognosis and stratify therapeutic protocols. 2. Molecular genetic components of lymphomagenesis, transformation and progression. 3. Signal transduction of receptors involved in induction of apoptosis such us Fas/CD95, receptors of TRAIL/APO2L and TGF-beta. 3. Molecular mechanisms of different forms of cell death. 4. The role of the extracellular matrix (ECM) in angiogenesis, invasion and metastasis, but also in carcinogenesis and drug sensitivity of tumour cells.

The Department welcomes Ph.D. students, pre- and post-doctoral young and senior researchers in the fields of Transformation and Progression of Lymphomas; New Molecular Diagnostic Methods in Pathology and Functional Genomics in Oncohematology; the Role of the ECM in Metastasis, Invasion, Cellular Motility and Drug Sensitivity of Tumour Cells; Signal Transduction of Death Receptor Induced Apoptosis (Fas, TRAIL-receptors); TGF-Beta-induced Apoptosis in Lymphomas for a few months and up to several years. Knowledge of English is necessary.

The Department would also like to take part in international Research and Development Projects.

3.4 Ph.D. School for Molecular Medical Sciences, Semmelweis University
(Multidiszciplinaris Molekularis-orvostudomanyi Doktori Iskola, Semmelweis Egyetem)

Contact:
Agota VER
Senior Lecturer
Ph.D. School for Molecular Medical Sciences
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry
Semmelweis University
P. O. Box 260, H-1444 Budapest, Hungary
+36 1 266 2755 ext. 4118
molorv@puskin.sote.hu

Research, a Short Introduction:
The postgraduate school of molecular medical sciences serves for both biomedical basic research and primary training of researchers starting their careers in the fields of clinical research. One short coming of biomedical research is that there is no efficient connection between basic and clinical research. Therefore, five main programs involve applied theoretical knowledge together with clinical research.

• Pathobiochemistry
• Cellular and Molecular Physiology
• Human Molecular Genetics and Gene Diagnostics
• Basic and Clinical Immunology
• Embryology, Theoretical, Experimental and Clinical Developmental Biology

The Institute welcomes Ph.D. students or pre-doctoral researchers in the fields of Biochemistry, Physiology, Molecular Biology, Immunology, Embryology for 1 academic year and more. Knowledge of English or German is essential.

The Ph.D. School would also like to participate in international Research and Development Projects.

3.4 Research Group for Apoptosis and Signoling, the Hungarian Academy of Sciences and University of Debrecen
(Jelatvitel es Apoptozis Kutatocsoport, Magyar Tudomanyos Akademia es Debreceni Egyetem)