Hungarian Scientific Research Fund No. T 037 297

Béla Csukás

University of Kaposvár

Institute of Mathematics and Information Technology

Guba Sandor u. 40., Kaposvar, 7400 Hungary

Phone: direct: +36-(82)-526-345

secretary: +36-(82)-314-155 / 210

mobil: +36-(30)-385-1061

fax: +36-(82)-320-746

· A new, discrete, structural model of the conservational processes was introduced. Based on the theoretical foundations, a methodology was developed for the direct, automatic mapping of the structural models onto an executable program or dynamic database.

· The network (ring) and net structure of the process models were studied. The informational process was interpreted as the transformation of a special part of the conservational process.

· The notion of evaluation feedback was introduced, and the evolutionary theory of the engineering synthesis and design was elaborated. A problem solving method, based on the feedback between the generic simulator and the genetic algorithm was developed.

· The new tools were successfully applied for the analysis, identification and design of batch polymerization reactors, of preparative (elution HPLC and SMB) chromatographic systems, of ion exchange technologies, of metabolic networks, etc.

The various quantitative and qualitative models can be mapped onto the so-called structural models, consisting of uniform passive and uniform active data structures, respectively. In the following period, we have to describe the new method in a formal language that helps to promote the necessary interdisciplinary collaboration. In a longer time horizon, it can be followed by the description of a so-called "conservational computer", consisting of the network of passive and active processors.

The identification and simulation of biochemical and biological processes will be studied more detailed, including the combination of the generic dynamic simulation with Metabolic Flux Analysis and Metabolic Control Analysis. In the modeling of the more complex processes, the conservational process will be partly mapped onto a homomorphic informational process.

The Almost Closed Conservational Process means a complex network of recycles that from a set of easily usable and easily recoverable intermediate materials produces a set of goal products while these goal materials or their final derivatives after the use can be transformed into the intermediate forms. The synthesis / design and the control of the Almost Closed Conservational Processes will be investigated by the evolutionary method, based on the feedback between the generic simulator and the genetic algorithm. The cooperative process architectures, formed in the closed space of the finite resources will also be studied.