OTKA T038270

Principal investigator:

Teréz Márián, Ph.D. Senior Scientist of the Pozitron Emission Tomograph Center, Medical Scool of Debrecen, Hungary.

Subject of the research project:

PET investigation of the binding kinetics of PET isotope-labelled ligands and adenosine receptors involved in the regulation of myocardial and CNS function

The adenosine occurs ubiquitaerly and plays an essential role in the maintenance of the homeostasis of the living organisms. It may be released from almost all kind of cells; it is also a neurotransmitter and possesses autocrine and paracrine regulating mechanism. In the frame of this project we plan the development of positron emitting isotope labelled A1 and A2 adenosine receptor ligands. Using this ligands we plan to investigate the biodistribution of the receptors, the dynamics of the binding process of the ligand and the regulating mechanisms that play central role in the function of the myocardium and the central nervous system.

It gives a special importance for the investigations that the PET isotope labelled ligands provide possibility parallel measurements the spatial and temperal distribution.

The protocols to be worked out and the results supposed to be achieved may provide the base for other receptor/ligand research at the PET Center of the University of Debrecen.